“The Penicillin is without a doubt the most iconic new-classic cocktail of the 21st century. Unlike more ancient drinks like the Manhattan and old-fashioned, whose origins are muddled and murky at best, we can trace the Penicillin to a specific person, time, and place. The drink was created by Australian bartender Sam Ross at the legendary speakeasy Milk & Honey, on New York City’s Lower East Side in 2005, right as the craft cocktail wave—which ushered in a new era of appreciation for the “lost” art of mixing drinks—was cresting.”